Research demonstrates alterations in steroidogenesis in aging males due to melatonin deficiency, implicating neurotrophins.
Using a model of melatonin deficiency in male rats of different ages (5-, 15-, and 20-month-old), we have demonstrated specific changes in the immune expression of broad spectrum of signalling molecules as neurotrophins ligand-receptor BDNF/trkB system, members of the tachykinin family Neurokinin B and Substance P and Cyclin D1 and Bcl6, regulators of the cell life cycle and apoptosis. The results obtained are indicative for the potential role of the molecules under study in the regulation of testicular steroidogenesis during aging and the involvement of melatonin in this process.
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Barbutska et al. (2025) studied this question.
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