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The study aims to assess how prolonged melatonin affects metabolic and hormonal variables in male and female Sprague-Dawley rats.

Prolonged melatonin administration in 6-month-old Sprague-Dawley rats: metabolic alterations

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The study aims to assess how prolonged melatonin affects metabolic and hormonal variables in male and female Sprague-Dawley rats.
Melatonin was administered in tap water (4 microg/ml) starting at 6 months of age for 12 weeks.
Rats were fed a standard diet ad libitum and maintained on a 12:12 hour light-dark regimen.
Melatonin decreased body mass in females throughout the experiment and in males after day 42.
Serum insulin decreased and corticosterone increased in both sexes, indicating hormonal alterations.
Cholesterol concentrations varied by sex, with increased levels in males and decreased levels in females.

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Randomized trial evaluates metabolic changes from prolonged melatonin in Sprague-Dawley rats, suggesting significant sex-dependent effects.

Bojková et al. (2008) studied this question.

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Randomized trial evaluates metabolic changes from prolonged melatonin in Sprague-Dawley rats, suggesting significant sex-dependent effects.