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September 10, 2025Biolohichni systemy

Glycogen Content and Glucose-6-Phosphatase Activity in the Liver of Rats With Dexamethasone Diabetes Under Conditions of Changed Photoperiod and Administration of Melatonin

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Authors

ІYІ.М. YaremiiОKО.Yu. KushnirKYK.M. Yaremii

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Overview

Research shows melatonin reduces glucose-6-phosphatase activity and maintains glycogen levels in rats, indicating potential metabolic benefits.

Key Points

  • Melatonin treatment maintained glycogen levels in rats with dexamethasone diabetes compared to untreated controls.
  • In rats with dexamethasone diabetes, glucose-6-phosphatase activity increased by 64.5% under all light conditions.
  • Dexamethasone-induced diabetes reduced liver glycogen by up to 17% depending on environmental light exposure.
  • Melatonin's ability to correct diabetes-related metabolic changes highlights its potential therapeutic role in this condition.

Cite This Study

Yaremii et al. (2024) studied this question.

synapsesocial.com/papers/68c1e17054b1d3bfb60fe8aahttps://doi.org/10.31861/biosystems2024.02.197
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Also Consider

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  4. 4Melatonin and Quercetin Co‐Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation2026 · 1 citations
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