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September 10, 2025Biolohichni systemy

The Role of Pyruvate in Energy Turnover of Rats With Alloxan Diabetes Under the Conditions of Melatonin Injections

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Authors

ОKО.Yu. KushnirОKО.Yu. KushnirІYІ.М. Yaremii

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Overview

Observational analysis reveals altered pyruvate levels in alloxan-diabetic rats, suggesting melatonin modulates glucose regulation.

Key Points

  • Pyruvate levels increased by 172% in alloxan-diabetic rats, while melatonin normalized these levels.
  • Administration of melatonin decreased fasting glucose levels by 38% compared to intact controls.
  • Under melatonin treatment, pyruvate in the plasma rose by 23%, indicating a shift towards aerobic energy processes.
  • This research suggests melatonin may enhance glucose entry into cells and improve energy supply.

Cite This Study

Kushnir et al. (2024) studied this question.

synapsesocial.com/papers/68c1e17054b1d3bfb60fe8a6https://doi.org/10.31861/biosystems2024.02.215
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