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May 13, 2025International Journal of Molecular SciencesOpen Access

Melatonin Improves Lipid Homeostasis, Mitochondrial Biogenesis, and Antioxidant Defenses in the Liver of Prediabetic Rats

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Authors

MSMilena Cremer de SouzaMAMaria Luisa Gonçalves AgneisMAMatheus Ribas de Almeida

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Overview

Experimental study reveals melatonin restores hepatic lipid metabolism and mitochondrial biogenesis in prediabetic rats, highlighting its therapeutic potential for early metabolic disease.

Key Points

  • To evaluate the protective effects of melatonin on energy metabolism, oxidative stress, and mitochondrial dynamics in the liver of prediabetic rats.
  • Prediabetes was induced in rats using chronic sucrose feeding alongside low-dose streptozotocin administration.
  • Prediabetic rats were treated with melatonin at a dosage of 20 mg/kg daily for four weeks.
  • Hepatic lipid and glucose parameters, mitochondrial enzyme activities, oxidative stress markers, and expression of genes regulating mitochondrial biogenesis and dynamics were quantified.
  • Melatonin significantly decreased circulating glucose, triglycerides, and total cholesterol while elevating hepatic high-density lipoprotein and stimulating β-oxidation enzymes.
  • Hepatic mitochondrial biogenesis and dynamics markers, notably PGC-1α, TFAM, and key fusion and fission regulators, were markedly restored following melatonin administration.
  • Melatonin mitigated oxidative stress by upregulating superoxide dismutase and catalase activities and reducing hepatic lipid peroxidation.

Cite This Study

Souza et al. (2025) studied this question.

synapsesocial.com/papers/6a97cfd0a2c7923eae15de3dhttps://doi.org/10.3390/ijms26104652
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