What question did this study set out to answer?

To evaluate the metabolic effects of an eight-week oral melatonin treatment on insulin and glucose tolerance in high-fat diet-fed mice and identify the underlying vascular mechanisms.

October 9, 2009Endocrinology

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice

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To evaluate the metabolic effects of an eight-week oral melatonin treatment on insulin and glucose tolerance in high-fat diet-fed mice and identify the underlying vascular mechanisms.
Treated diet-induced insulin-resistant mice and standard chow-fed control mice with oral melatonin for 8 weeks.
Assessed in vivo insulin sensitivity and glucose handling using hyperinsulinemic-euglycemic clamp studies and intraperitoneal glucose tolerance tests.
Measured vascular insulin signaling via Akt and endothelial nitric oxide synthase phosphorylation in isolated aortas, and evaluated in vitro skeletal muscle glucose uptake.
Melatonin significantly improved insulin sensitivity and glucose tolerance exclusively in high-fat diet-fed mice, requiring higher glucose infusion rates during hyperinsulinemic clamps and blunting the glycemic response to glucose challenge.
Melatonin restored insulin-induced vasodilation in skeletal muscle and enhanced insulin-stimulated phosphorylation of Akt and endothelial nitric oxide synthase in the vasculature.
Melatonin did not alter direct insulin-stimulated glucose uptake in isolated skeletal muscle tissue in vitro.

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Implication

Animal study reveals that melatonin improves glucose homeostasis by restoring vascular insulin sensitivity in obese mice, highlighting a novel therapeutic avenue for insulin resistance.

Cite This Study

Sartori et al. (2009) studied this question.

synapsesocial.com/papers/6a827874f337522b6774bb02 https://doi.org/10.1210/en.2009-0425

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Implication

Animal study reveals that melatonin improves glucose homeostasis by restoring vascular insulin sensitivity in obese mice, highlighting a novel therapeutic avenue for insulin resistance.

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice

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Discussion

Implication

Cite This Study

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice

Key Points

Discussion

Implication

Cite This Study

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