Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2024Delta University Scientific JournalOpen Access

Establishment of dexamethasone model as a model for metabolic-associated hepatic injury in male Wistar rats

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAhmed AmerGSGeorge S.G. ShehatouHGHamdy A. Ghoneim

Discussion

Loading...

Member takes

Overview

Preclinical study demonstrates metabolic-associated hepatic injury after dexamethasone exposure in male Wistar rats, highlighting a rapid model for fatty liver disease.

Key Points

  • Dexamethasone exposure successfully induced metabolic-associated hepatic injury in male Wistar rats, triggering hyperglycemia along with significant liver enlargement.
  • Assessment of rats given 8 mg/kg/day or 16 mg/kg/day dexamethasone showed marked increases in aspartate aminotransferase activity alongside leukocyte infiltration.
  • Supports rapid preclinical modeling of nonalcoholic fatty liver disease and insulin resistance; rat model, further preclinical work needed to evaluate interventions.

Cite This Study

Amer et al. (2024) studied this question.

synapsesocial.com/papers/68e7119db6db64358768b15fhttps://doi.org/10.21608/dusj.2024.254311.1044
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-Dose Dexamethasone Induces Whole-Body Insulin Resistance and Alters Both Cardiac Fatty Acid and Carbohydrate Metabolism2004 · 107 citations
  2. 2Dexamethasone-triggered hepatic and renal impairment in albino rats, and its amelioration through royal jelly intervention2024 · 1 citations
  3. 3THE INFLUENCE OF DEXAMETHASONE ON ADIPOSE TISSUE METABOLISM IN VITRO1967 · 22 citations
  4. 4GLYCOGEN CONTENT AND GLUCOSE-6-PHOSPHATASE ACTIVITY IN THE LIVER OF RATS WITH DEXAMETHASONE DIABETES UNDER CONDITIONS OF CHANGED PHOTOPERIOD AND ADMINISTRATION OF MELATONIN2024
  5. 5Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations2026