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July 31, 2025

Foxp3+ Regulatory T Cells Restrain Th1 Response Shielding the Brain from Lethal Inflammatory Damage during Cryptococcal Meningoencephalitis

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Authors

MOMichal A. OlszewskiHLHailong LiRHRylan Hissong

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Overview

Depletion of regulatory T cells exacerbates brain inflammation in cryptococcal meningoencephalitis, highlighting their potential therapeutic role.

Key Points

  • Regulatory T cells are essential for controlling inflammation in the brain during cryptococcal meningoencephalitis.
  • Treg depletion leads to increased brain inflammation and worsens neurological symptoms in experimental models.
  • Chemokine receptor CCR8 mediates the recruitment of Tregs to the CNS, crucial for their protective role.
  • Low dose IL-2-immune complex treatment enhances Treg function, improving survival and neurological outcomes in mice.

Cite This Study

Olszewski et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf32chttps://doi.org/10.21203/rs.3.rs-7142999/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central role of IL-10 in CNS-protection from Inflammatory Damage during Cryptococcus Meningoencephalitis 22539262026
  2. 2Tregs that accumulate in the encephalomyocarditis virus-infected mouse brain: Origin, compartmentalization, function, and gene signature2017
  3. 3Single-cell immune landscape of cerebrospinal fluid in non-HIV cryptococcal meningitis2026
  4. 4The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis2024 · 1 citations
  5. 5CNS1-induced Peripheral Regulatory T cells in the Resolution of Acute Lung Injury 21152025