Comparative review reveals how regulatory T cells promote myelin repair in central nervous system models, highlighting evolutionary pathways for potential therapies.
Key Points
To review how regulatory T cells promote central nervous system remyelination through neuro-immune interactions and compare these mechanisms between mammalian and regeneration-competent animal models.
Synthesized molecular and cellular evidence detailing regulatory T cell influence on oligodendrocyte lineage progression, astrocytes, and microglia during central nervous system repair.
Compared immune-mediated remyelination mechanisms between non-competent mammalian models and regeneration-competent species like zebrafish.
Regulatory T cells directly promote remyelination by enhancing oligodendrocyte maturation and modulating local microglial and astrocytic inflammatory responses.
Treg-driven regenerative effects operate in a temporally and geographically regulated, age-dependent manner within the lesion microenvironment.
Evolutionarily conserved regenerative pathways identified in competent species provide molecular targets to overcome mammalian repair limitations.