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June 20, 2026MedicinaOpen Access

Myelin Repair as a Neuroprotective Strategy for Multiple Sclerosis: From Bench to Bedside

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Authors

TBTima BattahVMVasilios MastorodemosESErich Struecker

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Overview

This review demonstrates how remyelination promotes neuroprotection in multiple sclerosis, suggesting therapeutic potential.

Key Points

  • The aim is to connect biological mechanisms of remyelination with clinical applications in multiple sclerosis.
  • Review of recent advances in in vivo techniques for assessing remyelination.
  • Analysis of clinical trials promoting remyelination therapies.
  • Discussion of challenges faced in advancing remyelination treatments beyond phase II.
  • Successful remyelination correlates with reduced disability progression in MS.
  • Evidence suggests that demyelinated axons are vulnerable, highlighting the need for effective remyelination strategies.
  • Identified challenges hindered advancements of remyelination therapies beyond phase II trials.

Cite This Study

Battah et al. (2026) studied this question.

synapsesocial.com/papers/6a363326db0793dc1a539828https://doi.org/10.3390/medicina62061183
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions2024 · 24 citations
  2. 2ELECTRON MICROSCOPIC FEATURES OF MULTIPLE SCLEROSIS LESIONS1965 · 209 citations
  3. 3The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes2013 · 227 citations
  4. 4Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination2013 · 142 citations
  5. 5Cortical Remyelination Is Heterogeneous in Multiple Sclerosis2017 · 78 citations