Review discusses mechanisms of remyelination via oligodendrocyte precursor cells and their crosstalk with glial cells, indicating new therapies for multiple sclerosis.
Key Points
Remyelination fails in demyelinated areas, leading to chronic lesions and disability.
Oligodendrocyte precursor cells are crucial for rebuilding the myelin sheath around axons.
Extracellular factors and intracellular signaling pathways dictate the differentiation of oligodendrocyte precursor cells.
Crosstalk between oligodendrocyte precursor cells and other glial cells affects remyelination processes.