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April 1, 1997Multiple Sclerosis Journal

Promotion of endogeneous remyelination in Multiple Sclerosis

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Key result

Manipulation of the immune response in experimental models indicates potential to promote endogenous CNS remyelination and functional recovery in Multiple Sclerosis.

Why the study?

Does manipulation of the immune response promote endogenous CNS remyelination and functional recovery in Multiple Sclerosis?

Population

Experimental models of CNS demyelination (specifically Theiler's virus model) and human Multiple Sclerosis

Design

Review

Authors

CLCF LucchinettiJNJ H NoseworthyMRMoses Rodriguez

Discussion

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Overview

Remyelination remains incomplete in MS; leaves open whether targeting repair factors improves outcomes.

Structured PICO

Does manipulation of the immune response promote endogenous CNS remyelination and functional recovery in Multiple Sclerosis?

P
Population
Experimental models of CNS demyelination (specifically Theiler's virus model) and human Multiple Sclerosis
I
Intervention
Manipulation of the immune response
O
Outcome
Promotion of endogenous CNS remyelination and functional recovery

Manipulation of the immune response in experimental models suggests potential for promoting endogenous CNS remyelination and functional recovery in Multiple Sclerosis.

Cite This Study

Lucchinetti et al. (1997) conducted a review in Multiple Sclerosis. Manipulation of the immune response was evaluated on Endogenous CNS remyelination and functional recovery. Manipulation of the immune response in experimental models indicates potential to promote endogenous CNS remyelination and functional recovery in Multiple Sclerosis.

synapsesocial.com/papers/6a6f181d35aa2c282ce07fc0https://doi.org/10.1177/135245859700300202
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