Supplementary Figure S1 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Richard C. Gregory; Neil Lineberry; Alexander Parent; Karthik Rajasekaran; Thomas J. Ow; Cherie‐Ann O. Nathan; Beryl A. Hatton; Wendy Jenkins; Marc Grenley; Connor Burns; Angela Merrell; Jason P. Frazier; Jonathan M.J. Derry; Emily Beirne; Richard A. Klinghoffer

doi:10.1158/2767-9764.29672764

July 30, 2025

Supplementary Figure S1 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

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Key Points

MAIN FINDING: Dazostinag shows significant proinflammatory effects on the tumor microenvironment in head and neck cancer patients.
KEY EVIDENCE: The CIVO Phase 0 clinical workflow demonstrates these effects in the context of chemotherapy.
APPROACH: The study used an in situ analysis to assess the interaction of dazostinag with the tumor microenvironment.
SIGNIFICANCE: These findings suggest potential therapeutic implications for improving chemotherapy outcomes in head and neck squamous cell carcinoma.

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Implication

CIVO Phase 0 trial reveals proinflammatory effects of dazostinag on the tumor microenvironment in patients with head and neck squamous cell carcinoma, highlighting its potential role in chemotherapy.

Abstract

Figure S1. CIVO Phase 0 clinical workflow

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Gregory et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf404 https://doi.org/10.1158/2767-9764.29672764

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Supplementary Figure S1 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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