Supplementary Information from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Richard C. Gregory; Neil Lineberry; Alexander Parent; Karthik Rajasekaran; Thomas J. Ow; Cherie‐Ann O. Nathan; Beryl A. Hatton; Wendy Jenkins; Marc Grenley; Connor Burns; Angela Merrell; Jason P. Frazier; Jonathan M.J. Derry; Emily Beirne; Richard A. Klinghoffer

doi:10.1158/2767-9764.29672737

July 30, 2025

Supplementary Information from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

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Key Points

MAIN FINDING: Dazostinag shows significant proinflammatory effects on the tumor microenvironment in head and neck cancer.
KEY EVIDENCE: The combination of dazostinag and chemotherapy alters the microenvironment, potentially worsening patient outcomes.
APPROACH: The research involved patient samples from head and neck squamous cell carcinoma to analyze drug interactions.
SIGNIFICANCE: Understanding these interactions can guide therapeutic strategies and improve cancer treatment outcomes.

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Implication

Research demonstrates proinflammatory effects of dazostinag with chemotherapy in head and neck squamous cell carcinoma, suggesting implications for treatment.

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Gregory et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf40a https://doi.org/10.1158/2767-9764.29672737

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Supplementary Information from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Information from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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