Supplementary Figure S4 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Richard C. Gregory; Neil Lineberry; Alexander Parent; Karthik Rajasekaran; Thomas J. Ow; Cherie‐Ann O. Nathan; Beryl A. Hatton; Wendy Jenkins; Marc Grenley; Connor Burns; Angela Merrell; Jason P. Frazier; Jonathan M.J. Derry; Emily Beirne; Richard A. Klinghoffer

doi:10.1158/2767-9764.29672755

July 30, 2025

Supplementary Figure S4 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

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Key Points

MAIN FINDING: Dazostinag, alone or with chemotherapy, influences cellular apoptosis in cancer therapy.
KEY EVIDENCE: Treatment outcomes observed at 24 and 72 hours indicate varied responses based on combinations.
APPROACH: A preclinical mouse model was used to assess the effects of dazostinag and chemotherapy on cancer cells.
SIGNIFICANCE: Findings may help improve treatment approaches for patients with head and neck squamous cell carcinoma.

Implication

Preclinical model reveals cellular apoptosis from dazostinag alone and combined with chemotherapy, suggesting potential treatment strategies.

Abstract

Figure S4. Cellular apoptosis with dazostinag alone, chemotherapy doublet, and dazostinag-chemotherapy triple combination in a preclinical mouse model after 24- and 72-hours of drug exposure.

Discussion

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Cite This Study

Gregory et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf3fe https://doi.org/10.1158/2767-9764.29672755

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Supplementary Figure S4 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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