Figure 4 from In Situ Proinflammatory Effects of Dazostinag Alone or with Chemotherapy on the Tumor Microenvironment of Patients with Head and Neck Squamous Cell Carcinoma

Dazostinag induces CXCL9 signaling and the recruitment of cytotoxic T cells. A, Representative images of a chemotherapy doublet site showing no changes in CXCL9 signaling or recruitment of T cells (left) and the dazostinag injection site surrounded by a characteristic ring of drug exposure demonstrating the induction of CXCL9 signaling and recruitment of CD8⁺ T cells (right). B, Quantification of T-cell activation. C, CosMx data showing increased numbers of T_Cell_GNLY cells that are diminished by combination with chemotherapy. The number of regions of interest analyzed for each patient and drug condition is detailed in Supplementary Table S4. CPPT, carboplatin; PTX, paclitaxel.