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July 31, 2025Current Protein and Peptide Science

Engineering Strategies for Hyaluronan Synthesis: A Review of Enzyme Modifications, Strain Selection, and Molecular Weight Control

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Authors

MEMortaza EivaziTETahereh EbrahimiKHKamran Hosseini

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Overview

Review uncovers enzyme modifications and strain engineering to control hyaluronan molecular weight, suggesting improved therapeutic efficacy.

Key Points

  • Hyaluronan is crucial in medical and cosmetic fields, with its molecular weight affecting biological function.
  • High-molecular-weight hyaluronan possesses anti-inflammatory properties, while low-molecular-weight variants are pro-inflammatory.
  • Genetic modification of strains enhances hyaluronan production efficiency and helps achieve desired molecular weights.
  • Current challenges include producing monodisperse hyaluronan with specific molecular properties for improved therapeutic applications.

Cite This Study

Eivazi et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf417https://doi.org/10.2174/0113892037367001250702064351
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Also Consider

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  1. 1Tailored molecular weight hyaluronic acid production by engineered Lactococcus lactis2026 · 3 citations
  2. 2Recent Advances in the Evolutionary Classification and Structural Insights of Hyaluronan Synthase2026 · 1 citations
  3. 3Rational structural design for the dual enhancement of catalytic activity and thermal stability of hyaluronidase from Citrobacter portucalensis2026
  4. 4Engineering Halomonas bluephagenesis TD01 as a Robust Chassis for the Sustainable Production of Hyaluronic Acid2026 · 1 citations
  5. 5Enzyme variants in biosynthesis and biological assessment of different molecular weight hyaluronan2024 · 5 citations