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June 13, 2026BiomoleculesOpen Access

Engineering Halomonas bluephagenesis TD01 as a Robust Chassis for the Sustainable Production of Hyaluronic Acid

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Authors

EMEhab Marwan-AbdelbasetXLXiaoyun LuDTDan Tan

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Overview

Randomized trial evaluates fermentation optimization for increased hyaluronic acid yield in Halomonas bluephagenesis TD01, indicating a significant advancement for biotechnological applications.

Key Points

  • The aim is to develop Halomonas bluephagenesis TD01 as a sustainable platform for hyaluronic acid production.
  • Heterologous expression of three hyaluronan synthase genes—sezHasA, spHasA, and pmHasA.
  • Optimization of fermentation conditions using Plackett–Burman design and response surface methodology.
  • Evaluation of HA yield and molecular weight adjustments.
  • Maximum HA yield improved from 0.88 g/L to 2.38 g/L (265% improvement).
  • Molecular weight of HA increased from 1.15 MDa to 9.67 MDa after optimization.
  • HA molecular weight tuning achieved from 2.04 MDa to 9.67 MDa with L-arabinose modulation.

Cite This Study

Marwan-Abdelbaset et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf57cfaef96ed7f0578achttps://doi.org/10.3390/biom16060846
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