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September 10, 2025

Hyaluronidases improve the hyaluronic acid yield during the fermentation of

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Authors

CKChuan-Li KangJiangnan University DZDongmei ZhengJingdezhen Ceramic Institute ZYZhi-Yuan YaoQingdao University

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Implication

Experimental analysis demonstrates enhanced hyaluronic acid production in Streptococcus zooepidemicus fermentation, suggesting enzymatic intervention optimizes yield.

Key Points

Hyaluronidases significantly improved hyaluronic acid yield during fermentation, addressing viscosity issues.
Adding EHya4 at 1500 U/L increased HA titer by 12%, outperforming others in enzymatic efficiency.
S. zooepidemicus fermentation was optimized through strategic HAase dosing, achieving 10.3 g/L HA concentration.
Balancing enzymatic degradation with microbial growth kinetics allows for scalable production of hyaluronic acid.

Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/68c1a77254b1d3bfb60e0838 https://doi.org/10.3389/fbioe.2025.1625009

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Implication

Experimental analysis demonstrates enhanced hyaluronic acid production in Streptococcus zooepidemicus fermentation, suggesting enzymatic intervention optimizes yield.