What question did this study set out to answer?

To assess the techno-economic feasibility of producing topical- and injectable-grade hyaluronic acid using Streptococcus zooepidemicus fermentation across batch and fed-batch configurations.

January 28, 2021ProcessesOpen Access

Techno-Economic Analysis of a Hyaluronic Acid Production Process Utilizing Streptococcal Fermentation

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Authors

RFRafael G. Ferreira AAAdriano Rodrigues Azzoni MSMaria Helena Andrade Santana

Discussion

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Overview

Techno-economic study demonstrates lower production costs for hyaluronic acid in fed-batch streptococcal cultures, indicating enhanced profitability from high-purity injectable grades.

Key Points

To assess the techno-economic feasibility of producing topical- and injectable-grade hyaluronic acid using Streptococcus zooepidemicus fermentation across batch and fed-batch configurations.
Simulated bioprocess production of hyaluronic acid in SuperPro Designer across batch and fed-batch fermentation models.
Evaluated downstream recovery operations comprising centrifugation, diafiltration, activated carbon purification, and isopropanol precipitation.
Modeled operational scenarios diverting 10% of precipitated hyaluronic acid to high-purity, high-molecular-weight processing for injectable applications.
Baseline batch fermentation yielding 2.5 g/L after 24 hours resulted in an estimated production cost of 1115 $/kg for topical formulations.
Fed-batch fermentation achieving a titer of 5.0 g/L decreased the unit production cost to 946 $/kg.
Diverting 10% of output to injectable-grade specifications increased capital and operating costs, but higher selling prices substantially increased net profitability.

Cite This Study

Ferreira et al. (2021) studied this question.

synapsesocial.com/papers/6aaf7e0766ccc072b425dc9b https://doi.org/10.3390/pr9020241

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January 28, 2021ProcessesOpen Access

Techno-Economic Analysis of a Hyaluronic Acid Production Process Utilizing Streptococcal Fermentation

View Full Paper

Ask AI

Bookmark

Authors

RFRafael G. Ferreira AAAdriano Rodrigues Azzoni MSMaria Helena Andrade Santana

Discussion

Member takes

Overview

Techno-economic study demonstrates lower production costs for hyaluronic acid in fed-batch streptococcal cultures, indicating enhanced profitability from high-purity injectable grades.

Key Points

To assess the techno-economic feasibility of producing topical- and injectable-grade hyaluronic acid using Streptococcus zooepidemicus fermentation across batch and fed-batch configurations.
Simulated bioprocess production of hyaluronic acid in SuperPro Designer across batch and fed-batch fermentation models.
Evaluated downstream recovery operations comprising centrifugation, diafiltration, activated carbon purification, and isopropanol precipitation.
Modeled operational scenarios diverting 10% of precipitated hyaluronic acid to high-purity, high-molecular-weight processing for injectable applications.
Baseline batch fermentation yielding 2.5 g/L after 24 hours resulted in an estimated production cost of 1115 $/kg for topical formulations.
Fed-batch fermentation achieving a titer of 5.0 g/L decreased the unit production cost to 946 $/kg.
Diverting 10% of output to injectable-grade specifications increased capital and operating costs, but higher selling prices substantially increased net profitability.

Cite This Study

Ferreira et al. (2021) studied this question.

synapsesocial.com/papers/6aaf7e0766ccc072b425dc9b https://doi.org/10.3390/pr9020241

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