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June 19, 2026BiomoleculesOpen Access

Sustainable Production of High-Performance Antimicrobial Scaffold via an Engineered Halomonas Dual-Product Factory

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Authors

EMEhab Marwan-AbdelbasetXLXiaoyun LuDTDan Tan

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Overview

Randomized trial demonstrates antimicrobial potential of dual-product scaffold in microbial strains, indicating innovative wound management solutions.

Key Points

  • The aim is to develop a sustainable biorefinery method for producing hyaluronic acid and polyhydroxybutyrate from engineered Halomonas.
  • Utilized engineered Halomonas bluephagenesis TD01 in one-pot fermentation process.
  • Cultivated in nutrient-rich 40-LBG-Y medium achieving balanced metabolic flux.
  • Constructed bioactive HA-PHB nanoparticle scaffold with specific architectural properties.
  • Yielded 1.99 g/L high-molecular-weight hyaluronic acid (9.6 × 10^6 Da) and intracellular polyhydroxybutyrate (0.68 to 1.6 g/L).
  • Scaffold showed antimicrobial activity against Staphylococcus aureus, Klebsiella variicola, and Candida albicans.
  • Halomonas-derived HA outperformed Moringa oil in antimicrobial effectiveness against pathogens.

Cite This Study

Marwan-Abdelbaset et al. (2026) studied this question.

synapsesocial.com/papers/6a34df4a65a5b0777af2e717https://doi.org/10.3390/biom16060889
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