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September 10, 2025Journal of Applied Polymer ScienceOpen Access

Antimicrobial Behavior of Simvastatin‐Loaded Solution Blow‐Spun PLA/PEO/HA Scaffolds

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Authors

JCJoão P. A. CaribéLFLucas R. F. FigueiredoRARafaela R. Arimatéia

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Overview

Observational analysis shows enhanced antimicrobial functionality in PLA/PEO/HA scaffolds, indicating better infection prevention.

Key Points

  • Incorporating simvastatin into hybrid scaffolds significantly improves antimicrobial properties against S. aureus.
  • The scaffolds exhibit a water-in-air contact angle of 0°, enhancing their wettability and suitability for bone applications.
  • Cell viability tests confirm that the developed scaffolds are noncytotoxic to fibroblast cells over the incubation period.
  • The release behavior of simvastatin from the scaffolds is influenced by the amount of hydroxyapatite used in the formulation.

Cite This Study

Caribé et al. (2025) studied this question.

synapsesocial.com/papers/68c1aabf54b1d3bfb60e2f61https://doi.org/10.1002/app.57756
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