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July 31, 2025

Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy

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Authors

QDQing DuanZFZhi Yi FangSSSara Stickley

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Overview

Integration of polygenic risk scores with human milk components predicts atopy in infants, suggesting tailored interventions.

Key Points

  • Core findings reveal human milk components affect childhood atopy risk contingent on genetic predisposition.
  • Network analyses indicate a connection between specific microbes and oligosaccharides, related to atopy prevalence.
  • The gradient-boosting model predicts childhood atopy with an AUC of 0.78, showing superior accuracy with combined factors.
  • Insights into gene-milk interactions may lead to personalized strategies for reducing atopy risk in children.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf4afhttps://doi.org/10.21203/rs.3.rs-7143108/v1
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