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July 31, 2025Open Access

HCG22 as a Non-Invasive Saliva-Based lncRNA Diagnostic Marker for Oral Cancer: Evidence from an Indian Clinical Study

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Authors

PKPandikannan KrishnamoorthyARAthira S. RajSSSalendra Singh

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Overview

Clinical validation of lncRNA HCG22 as a non-invasive diagnostic marker for OSCC, suggesting its potential in early detection.

Key Points

  • HCG22 is a non-invasive lncRNA that shows potential as a diagnostic marker for OSCC.
  • In saliva samples, HCG22 demonstrated high diagnostic performance with an AUROC of 0.76, facilitating detection.
  • Clinical validation involved robust lncRNA analysis and RT-PCR in an Indian OSCC cohort, establishing relevance.
  • Lower levels of HCG22 are linked to advanced OSCC stages and poorer survival outcomes in patients.

Cite This Study

Krishnamoorthy et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf560https://doi.org/10.1101/2025.07.30.25332447
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Also Consider

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  4. 4Salivary Exosomal MicroRNAs as Non-Invasive Biomarkers for Early Detection of Oral Squamous Cell Carcinoma: A Prospective Diagnostic Study2025 · 1 citations
  5. 5Investigating diagnostic potential of long non-coding RNAs in head and neck squamous cell carcinoma using TCGA database and clinical specimens2024 · 10 citations