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November 28, 2025International Journal of Molecular SciencesOpen Access

Identification of a Novel Salivary Four-miRNA Signature for Non-Invasive Diagnosis of Oral Squamous Cell Carcinoma

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Authors

ACAlessia CiringioneGLGiovanni LilloniLTLucas Moron Dalla Tor

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Overview

Analysis reveals a novel four-miRNA signature in OSCC, suggesting non-invasive diagnostic potential for early detection.

Key Points

  • Salivary biomarkers indicate a potential breakthrough for non-invasive OSCC diagnosis.
  • Key findings show specificity of 96.7% and sensitivity of 86.7% for the four-miRNA signature.
  • Reverse transcription was integral to the analysis of miRNA expression in saliva samples.
  • Findings suggest the need for larger studies to confirm the diagnostic value of these biomarkers.

Cite This Study

Ciringione et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a7b3https://doi.org/10.3390/ijms262311373
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a Novel Salivary Four-miRNA Signature for Non-Invasive Diagnosis of Oral Squamous Cell Carcinoma2025
  2. 2Novel Disease-Specific Panel of Salivary microRNAs for the Detection of Oral Squamous Cell Carcinoma from Early Invasion to Stage IV Disease2026
  3. 3Salivary Exosomal MicroRNAs as Non-Invasive Biomarkers for Early Detection of Oral Squamous Cell Carcinoma: A Prospective Diagnostic Study2025 · 1 citations
  4. 4Circulating microRNAs: a new era in early detection of oral squamous cell carcinoma (OSCC) — a systematic review and meta-analysis2026
  5. 5Expression Analysis of Circulating microRNAs in Saliva and Plasma for the Identification of Clinically Relevant Biomarkers for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders2024 · 12 citations