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August 13, 2026Journal of the Egyptian National Cancer InstituteOpen Access

Circulating microRNAs: a new era in early detection of oral squamous cell carcinoma (OSCC) — a systematic review and meta-analysis

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Implication

Systematic review evaluates the diagnostic potential of circulating microRNAs in oral squamous cell carcinoma, highlighting heterogeneity in findings.

Key Points

  • This research aims to evaluate the diagnostic accuracy of circulating miRNAs for early detection of oral squamous cell carcinoma (OSCC).
  • Conducted a systematic review and meta-analysis following PRISMA-DTA 2020 guidelines.
  • Included articles evaluating circulating miRNAs in any biofluid for diagnosing OSCC.
  • Utilized a Bayesian bivariate random-effects model to analyze sensitivity, specificity, and odds ratios.
  • Pooled sensitivity of circulating miRNAs for detecting OSCC was 0.89 (95% CI: 0.77-0.95).
  • Pooled specificity was 0.88 (95% CI: 0.75-0.95) with a diagnostic odds ratio of 59.69 (95% CI: 14.33-209.95).
  • Substantial heterogeneity across studies was observed with wide credible intervals.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75c72b0e0cff3f63e9b5https://doi.org/10.1186/s43046-026-00393-4
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Also Consider

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