July 31, 2025Current Issues in Molecular BiologyOpen Access

CTC-537E7.3 as a Liver-Specific Biomarker for Hepatocellular Carcinoma: Diagnostic and Prognostic Implications

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Authors

HKHyung Seok KimYale Cancer Center SJSeonghoe JangPohang University of Science and Technology GBGeum Ok BaekAjou University

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Implication

Analysis reveals CTC-537E7.3 as a promising biomarker for hepatocellular carcinoma, indicating enhanced diagnostic and prognostic capabilities in patients.

Key Points

CTC-537E7.3 is the most consistently down-regulated long non-coding RNA in hepatocellular carcinoma, linked to early detection.
In a validation study, CTC-537E7.3 expression was absent in 95% of tumor samples, achieving an AUC of 0.95 for diagnostic accuracy.
Low CTC-537E7.3 levels correlate with shorter overall survival, revealing its prognostic potential in HCC patients.
The study uncovers a ceRNA axis involving CTC-537E7.3 and PLGLB1, suggesting a role in tumor suppression and patient outcomes.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf6e5 https://doi.org/10.3390/cimb47070563

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Implication

Analysis reveals CTC-537E7.3 as a promising biomarker for hepatocellular carcinoma, indicating enhanced diagnostic and prognostic capabilities in patients.

CTC-537E7.3 as a Liver-Specific Biomarker for Hepatocellular Carcinoma: Diagnostic and Prognostic Implications

Discussion

Member takes

Implication

Key Points

Cite This Study

CTC-537E7.3 as a Liver-Specific Biomarker for Hepatocellular Carcinoma: Diagnostic and Prognostic Implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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