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July 31, 2025Health Science ReportsOpen Access

Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review

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Authors

FPFarideh PargarMFMaryam FarjamfarSGShahrbanoo Goli

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Overview

Systematic review shows association of vitamin D, E, and selenium with ovarian reserve in women, suggesting potential preventive strategies.

Key Points

  • The review assessed the role of vitamins D, E, and selenium in relation to premature ovarian insufficiency (POI).
  • Of 2067 studies, 12 were included, involving 521 women, examining antioxidant vitamins and their effect on ovarian reserve.
  • Findings indicated that lower levels of vitamins D, E, and selenium correlate with reduced ovarian reserve markers in women.
  • Potential vitamin supplementation could improve AMH levels and lower FSH, offering new approaches to manage POI.

Cite This Study

Pargar et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf72bhttps://doi.org/10.1002/hsr2.71136
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between vitamin D levels, hormonal profile, and ovarian reserve in infertile women2026
  2. 2Excessive Vitamin E Supplementation: Implications for Ovarian Physiology and Reproductive Health2026
  3. 3Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants2023 · 166 citations
  4. 4The Association between Selenium and Epithelial Ovarian Cancer among Women: A methodology and comments from the Systematic Review and Meta-analysis2024
  5. 5The Correlation Between Serum Levels of 25-OH Vitamin D and Ovarian Reserve Parameters in Infertile Women2024 · 2 citations