July 31, 2025

Gastric microbiome in gastric cancer sequence depicts diverse microbial structures associated with cancer risk and prognosis

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Microbial α-diversity changes correlate with the occurrence and progression of gastric cancer.
Increased microbial diversity in primary gastric cancer tissue suggests a complex relationship with tumorigenesis.
Specific bacteria groups are linked to gastric cancer features like TP53 mutation and telomere shortening.
Findings highlight the need for further exploration of non-Helicobacter pylori microbiota in cancer diagnosis and treatment.

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Characterization reveals diverse microbial structures influencing gastric cancer risk and outcomes, indicating key roles of TP53 and methylation.

Shimogama et al. (2025) studied this question.

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Characterization reveals diverse microbial structures influencing gastric cancer risk and outcomes, indicating key roles of TP53 and methylation.