July 4, 2024Cellular OncologyOpen Access

Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer

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Gastric carcinogenesis alters mucosal bacterial diversity, with tumoral microbiota showing enriched nitrate reductase genes alongside distinct plasma metabolites.
A discriminatory panel of 81 plasma metabolites distinguishes gastric cancer from gastritis, while 15 metabolites separate patients by Helicobacter pylori status.
Analysis with 16S rRNA gene sequencing and gas chromatography mass spectrometry highlights mucosal signatures that may enable minimally invasive gastric cancer surveillance.

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Implication

Multiomics analysis reveals distinct bacterial and metabolic shifts in gastric cancer patients, highlighting potential biomarkers for minimally invasive diagnosis.

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e615d9b6db6435875a86c2 https://doi.org/10.1007/s13402-024-00965-3

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Implication

Multiomics analysis reveals distinct bacterial and metabolic shifts in gastric cancer patients, highlighting potential biomarkers for minimally invasive diagnosis.

Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer

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Discussion

Implication

Cite This Study

Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer

Key Points

Discussion

Implication

Cite This Study

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