July 31, 2025Open Access

Understanding the Causal Impact of Elevated Maternal Stress During Pregnancy: A Systematic Literature Review of Guinea Pig Models

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Systematic review uncovers negative effects of maternal stress on fetal development in guinea pigs, indicating a need for pre-conception studies.

Increased maternal stress during pregnancy is linked to adverse outcomes like preterm birth and impaired fetal development.
The review synthesizes findings from 41 studies on maternal stress in guinea pig models, revealing significant neurodevelopmental outcomes.
Guinea pigs provide better physiological parallels to humans compared to rodent models, making them relevant for studying maternal stress effects.
Future research should focus on pre-conception interventions to better emulate human pregnancy conditions and maternal adaptations.

Louis‐Jacques et al. (2025) studied this question.

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Systematic review uncovers negative effects of maternal stress on fetal development in guinea pigs, indicating a need for pre-conception studies.