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July 31, 2025Cerebrovascular Diseases

Intra-arterial Fibrinolysis Post Successful Endovascular Reperfusion for Acute Ischemic Stroke: A Systematic Review and Meta-analysis

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Authors

JZJiayi ZhangTMTong MengZDZhibo Deng

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Overview

Systematic review finds intra-arterial fibrinolysis can improve functional outcomes in stroke patients, suggesting its role alongside endovascular thrombectomy.

Key Points

  • Adjunctive intra-arterial fibrinolysis shows a mild enhancement in excellent functional recovery for stroke patients after endovascular thrombectomy.
  • Results indicate functional independence at 90 days did not significantly improve with intra-arterial fibrinolysis compared to thrombectomy alone.
  • Four randomized controlled trials with a total of 1,392 participants were analyzed to assess treatment efficacy and safety in stroke cases.
  • Study highlights the need for more high-quality trials to optimize intra-arterial fibrinolysis protocols and refine patient selection.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf7fahttps://doi.org/10.1159/000547702
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