What type of study is this?

This is a Systematic Review study (also classified as: Meta-Analysis).

October 16, 2025Brain CirculationOpen Access

The problem of hypoperfusion despite recanalization: A systematic review and meta-analysis of randomized clinical trials of intra-arterial thrombolysis as an adjunct to successful recanalization

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Authors

YQYue QiaoVascular / Pulmonary Vascular ASAdrien ter SchiphorstCentre National de la Recherche Scientifique YXYi XuShanghai Jiao Tong University

Discussion

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Implication

Systematic review reveals intra-arterial thrombolysis improves functional outcomes in acute ischemic stroke, suggesting selective use may be beneficial.

Key Points

Intra-arterial thrombolysis improves rates of excellent functional outcomes after endovascular thrombectomy.
Risk ratio for excellent outcomes was 1.24, indicating potential benefits for selected patients.
Significant benefits were found in patients with eTICI 2b reperfusion but not in those with eTICI 2c/3.
No increase in mortality or symptomatic intracerebral hemorrhage at 90 days was observed.

Cite This Study

Qiao et al. (2025) studied this question.

synapsesocial.com/papers/68f0f51d8dd8ea469b1d6dd3 https://doi.org/10.4103/bc.bc_101_25

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Implication

Systematic review reveals intra-arterial thrombolysis improves functional outcomes in acute ischemic stroke, suggesting selective use may be beneficial.

The problem of hypoperfusion despite recanalization: A systematic review and meta-analysis of randomized clinical trials of intra-arterial thrombolysis as an adjunct to successful recanalization

Discussion

Member takes

Implication

Key Points

Cite This Study

The problem of hypoperfusion despite recanalization: A systematic review and meta-analysis of randomized clinical trials of intra-arterial thrombolysis as an adjunct to successful recanalization

Discussion

Member takes

Implication

Key Points

Cite This Study

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