What question did this study set out to answer?

The research aims to evaluate the efficacy and safety of intra-arterial thrombolytic agents post-endovascular thrombectomy for acute ischemic stroke.

February 2, 2026Stroke

Abstract WP002: Safety and Efficacy of Intra-Arterial Thrombolysis After Endovascular Thrombectomy for Large-Vessel Occlusion: A Dose-Wise Network Meta-analysis of Randomized Trials

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Authors

MAMariya AliJamia Hamdard RRRishu RajAtal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital ASArkansh SharmaGovernment Medical College

Discussion

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Implication

Network meta-analysis demonstrates that adjunct intra-arterial thrombolysis improves outcomes in acute ischemic stroke, suggesting further study is needed.

Key Points

The research aims to evaluate the efficacy and safety of intra-arterial thrombolytic agents post-endovascular thrombectomy for acute ischemic stroke.
Analyzed randomized controlled trials comparing EVT alone vs EVT plus IA thrombolysis.
Searched multiple databases for studies up to October 2025.
Primary outcomes measured included functional recovery (mRS 0-1) at 90 days and safety outcomes (ICH, mortality).
Utilized random-effects frequentist network meta-analysis with odds ratios calculated.
Eight RCTs with 2,148 patients showed improved functional independence with EVT plus alteplase and tenecteplase.
Alteplase 0.225 mg/kg increased functional independence (OR 1.98), while Tenecteplase 0.125 mg/kg also showed benefits (OR 1.90).
No increased risk of intracerebral hemorrhage was found with IA agents across seven RCTs.
Mortality rates were similar between IA thrombolysis regimens and EVT alone in six RCTs.

Cite This Study

Ali et al. (2026) studied this question.

synapsesocial.com/papers/6980fcd6c1c9540dea80ea00 https://doi.org/10.1161/str.57.suppl_1.wp002

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Implication

Network meta-analysis demonstrates that adjunct intra-arterial thrombolysis improves outcomes in acute ischemic stroke, suggesting further study is needed.

Abstract WP002: Safety and Efficacy of Intra-Arterial Thrombolysis After Endovascular Thrombectomy for Large-Vessel Occlusion: A Dose-Wise Network Meta-analysis of Randomized Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract WP002: Safety and Efficacy of Intra-Arterial Thrombolysis After Endovascular Thrombectomy for Large-Vessel Occlusion: A Dose-Wise Network Meta-analysis of Randomized Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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