What question did this study set out to answer?

This research aims to assess the effectiveness and safety of specific doses of intra-arterial thrombolysis agents after endovascular thrombectomy for large-vessel occlusion stroke.

April 3, 2026Stroke Vascular and Interventional NeurologyOpen Access

Dose-Specific Intra-Arterial Thrombolysis After Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: A Network Meta-Analysis of Randomized Trials

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Authors

LFLuiz Eduardo Caliman FrechianiUniversidade Vila Velha HLHelena Libardi LouzadaSanta Casa Hospital

Discussion

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Implication

Network meta-analysis evaluates dose-specific intra-arterial thrombolysis effects in acute ischemic stroke, suggesting further research is necessary.

Key Points

This research aims to assess the effectiveness and safety of specific doses of intra-arterial thrombolysis agents after endovascular thrombectomy for large-vessel occlusion stroke.
Systematic search of databases for randomized controlled trials
Analysis of treatments including alteplase, tenecteplase, and urokinase
Frequentist random-effects network meta-analysis
Calculation of odds ratios with confidence intervals
Assessment of risk of bias and evidence certainty
IA alteplase 0.225 mg/kg exhibited higher odds for excellent functional recovery compared to control
Tenecteplase 0.125 mg/kg also showed favorable recovery odds
Lower-dose tenecteplase and urokinase exhibited reduced effects
No significant differences in symptomatic intracranial hemorrhage or 90-day mortality
Low global heterogeneity and inconsistency across outcomes

Cite This Study

Frechiani et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ea85a333a821460d36e https://doi.org/10.1161/svin.125.002292

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Implication

Network meta-analysis evaluates dose-specific intra-arterial thrombolysis effects in acute ischemic stroke, suggesting further research is necessary.

Dose-Specific Intra-Arterial Thrombolysis After Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: A Network Meta-Analysis of Randomized Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Dose-Specific Intra-Arterial Thrombolysis After Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: A Network Meta-Analysis of Randomized Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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