Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 2025Open Access

Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions

View Full Paper
Ask AI
Bookmark
Share

Authors

KGKhanisyah Erza GumilarAHAlexander Indra HumalaMWManggala Pasca Wardhana

Discussion

Loading...

Member takes

Overview

Cross-sectional study reveals altered dNK cell and B7-H3 expression in preeclampsia, suggesting immune tolerance loss.

Key Points

  • Preeclamptic placentas show higher dNK cell expression compared to normotensive controls, indicating immune response alteration.
  • B7-H3 expression is significantly lower in preeclamptic placentas, highlighting a potential loss of immune regulation.
  • A positive correlation exists between B7-H3 and dNK cell expression, particularly strong in normotensive pregnancies.
  • These findings indicate B7-H3's potential role as a biomarker for early prediction and prevention in preeclampsia.

Cite This Study

Gumilar et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cfb9fhttps://doi.org/10.20944/preprints202507.2596.v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunological Profiling of CD8+ and CD8− NK Cell Subpopulations and Immune Checkpoint Alterations in Early-Onset Preeclampsia and Healthy Pregnancy2024 · 1 citations
  2. 2Pregnancy-induced NK cells of importance to gravidity and preeclampsia2026
  3. 3Revealing an enhanced cytotoxic immune microenvironment at the human maternal–fetal interface in preeclampsia2026
  4. 4Impact of the Immunomodulatory Factor Soluble B7-H4 in the Progress of Preeclampsia by Inhibiting Essential Functions of Extravillous Trophoblast Cells2024 · 3 citations
  5. 5Immunology of Normal Pregnancy and Preeclampsia and the Role of Placental Non-Classical HLA and Decidual NK Cells2026