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May 27, 2026The Journal of Immunology

Pregnancy-induced NK cells of importance to gravidity and preeclampsia

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Authors

LAL ANDERSENUniversity of CopenhagenLKLaura A KimmerslevUniversity of CopenhagenNPNanna Heldager PedersenUniversity of Copenhagen

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Implication

Randomized trial investigates NK cell changes during pregnancy and their link to preeclampsia in women.

Key Points

  • To investigate immunological changes in NK cells associated with pregnancy and their implications for preeclampsia.
  • Analyzed NK cell subpopulations in peripheral blood of primigravid and multigravid women.
  • Conducted clinical comparisons between preeclampsia and control pregnancies.
  • Utilized human trophoblast-derived cell model to study mechanisms affecting NK cell induction.
  • Increased CD56brightCD16−ILT2+ NK cells in multigravid women compared to primigravid women.
  • Higher cytotoxic CD56dimCD16+ NK cells were found in primigravid women with preeclampsia.
  • Lower frequency of CD56brightCD16+ NK cells in multigravid controls, indicating differential induction in preeclampsia cases.

Cite This Study

ANDERSEN et al. (2026) studied this question.

synapsesocial.com/papers/6a1689ce0c924ddd1bd58832https://doi.org/10.1093/jimmun/vkag027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis1997 · 706 citations
  2. 2Pre-eclampsia: pathophysiology and clinical implications2019 · 1,268 citations
  3. 3Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia2023 · 44 citations
  4. 4A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells1999 · 729 citations
  5. 5A Phenotypic Analysis of Regulatory T Cells and Uterine NK Cells from First Trimester Pregnancies and Associations with HLA ‐G2015 · 29 citations