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August 1, 2025Virchows ArchivOpen Access

Atypical lymphoproliferations associated with germline genetic variants: a report of the 2024 EA4HP/SH lymphoma workshop

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Authors

MBMichiel van den BrandLRLívia Rásó‐BarnettGGGorana Gašljević

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Overview

Workshop demonstrates the complexity of lymphoproliferations in primary immunodeficiencies, suggesting deeper genetic links to malignancy.

Key Points

  • Atypical lymphoproliferations were discussed in relation to germline genetic variants during the 2024 lymphoma workshop.
  • Primary immunodeficiencies showed varied lymphoproliferations, including autoimmune lymphoproliferative syndrome and common variable immune deficiency.
  • Determining the relationship between lymphoproliferations and genetic defects, especially in non-immunodeficient patients, poses challenges.
  • Recognizing underlying PIDs can guide specific treatment approaches and influence the interpretation of lymphoproliferative disorders.

Cite This Study

Brand et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfc4bhttps://doi.org/10.1007/s00428-025-04189-0
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Germline Predisposition in Hematologic Malignancies: Testing, Management, and Implications2024 · 23 citations
  2. 2A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation2011 · 181 citations
  3. 3Germline predisposition to hematopoietic malignancies2021 · 29 citations
  4. 4Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations2014 · 228 citations