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December 8, 2025BloodOpen Access

The genetic landscape of lymphoma: Insights from a primary immunodeficiency NGS panel in lymphoma patients

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Authors

LFLindsay FogelTFTatyana Feldman

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Overview

Next generation sequencing identifies molecular pathways in lymphoma associated with primary immunodeficiency, suggesting immune defects influence cancer risk.

Key Points

  • To examine the genetic factors linking primary immunodeficiency and lymphoma through next generation sequencing.
  • Single center study involving 61 lymphoma patients
  • Patients underwent next generation sequencing targeting 574 genes related to primary immunodeficiency
  • Data collection included lymphoma type, treatment regimen, and gene analysis
  • 41 patients diagnosed with lymphoma, various subtypes identified
  • Median of 5 mutations per patient with VUS prevalent
  • Recurring mutations identified in CTCL, DLBCL, PTCL, and HL suggest common pathways

Cite This Study

Fogel et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d574https://doi.org/10.1182/blood-2025-7069
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