What question did this study set out to answer?

To assess the clinical and molecular features of lymphoid malignancies in a Brazilian cohort using next generation sequencing.

December 8, 2025Blood

Implementation of a next generation sequencing painel for lymphoid malignancies in Brazil: First report of molecular features in a low-middle income country

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Authors

PRPM ResendeHospital Israelita Albert Einstein LCLuiz Gustavo Ferreira CortêsHospital Israelita Albert Einstein WBWKP BarrosHospital Israelita Albert Einstein

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Implication

Analysis reveals high tumor mutational burden and actionable mutations in Brazilian patients with lymphoid malignancies, suggesting significant diagnostic and therapeutic implications.

Key Points

To assess the clinical and molecular features of lymphoid malignancies in a Brazilian cohort using next generation sequencing.
Retrospective analysis of 57 patients with mature lymphoproliferative disorders
Molecular testing employed a targeted next generation sequencing panel
Patient demographics and mutation profiles were analyzed
95% of patients had at least one identified molecular alteration
Median tumor mutational burden was 4.7 mut/Mb
26 patients (46%) had actionable biomarkers, emphasizing the potential for targeted therapy

Cite This Study

Resende et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d575 https://doi.org/10.1182/blood-2025-7066

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Implication

Analysis reveals high tumor mutational burden and actionable mutations in Brazilian patients with lymphoid malignancies, suggesting significant diagnostic and therapeutic implications.

Implementation of a next generation sequencing painel for lymphoid malignancies in Brazil: First report of molecular features in a low-middle income country

Discussion

Member takes

Implication

Key Points

Cite This Study

Implementation of a next generation sequencing painel for lymphoid malignancies in Brazil: First report of molecular features in a low-middle income country

Discussion

Member takes

Implication

Key Points

Cite This Study

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