What question did this study set out to answer?

To characterize the genomic landscape of DLBCL in Latin American countries, focusing on Brazil and Chile.

December 8, 2025Blood

Uncovering the genomic landscape of DLBCL in Latin America: First report of two centers from Brazil and Chile

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Molecular profiling reveals a high tumor mutational burden in DLBCL cohort from Latin America, indicating distinct genetic risks.

To characterize the genomic landscape of DLBCL in Latin American countries, focusing on Brazil and Chile.
Retrospective analysis of DLBCL patients from Brazil and Chile
Utilized targeted NGS panels for molecular profiling
Classified patients using LymphPlex classification system
All patients had at least one molecular alteration
Median tumor mutational burden was 11.4 mut/Mb
High prevalence of TP53 mutations noted in the cohort

Schmidt et al. (2025) studied this question.

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