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This study aims to analyze the baseline clinical characteristics and molecular findings of CLL patients across Latin America.

December 8, 2025BloodOpen Access

Baseline clinical characteristics of patients with chronic lymphocytic leukemia (CLL) from 11 Latin American countries: A real-world registry analysis

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Registry analysis reveals TP53 mutations and β2-microglobulin impact outcomes in chronic lymphocytic leukemia patients in Latin America.

This study aims to analyze the baseline clinical characteristics and molecular findings of CLL patients across Latin America.
Retrospective data collected from 4,649 CLL patients diagnosed between 2000 and 2024.
Involves 11 countries in Latin America, including Brazil and Argentina.
Analysis of staging, molecular findings, and outcomes based on registry data.
Median age at diagnosis was 67 years with male predominance.
62.1% of patients were stage A at diagnosis, significant proportion had high-risk features like TP53 mutations.
Five-year overall survival lower in patients with elevated β2-microglobulin compared to normal levels.

Arrais-Rodrigues et al. (2025) studied this question.

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