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December 8, 2025Blood

Discovering the epidemiology, treatment patterns, and outcomes of chronic lymphocytic leukemia: A retrospective multicenter cohort study

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Authors

CMCaldirola MariaCentro de Educación Médica e Investigaciones Clínicas Norberto QuirnoRSRodrigo SantacruzUniversidad Columbia del ParaguayBAB. Arntzenius AlexUniversidad Nacional de Asunción

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Overview

Retrospective analysis reveals treatment patterns and survival outcomes in chronic lymphocytic leukemia in developing countries, highlighting access issues.

Key Points

  • This research aims to assess the epidemiology, treatment patterns, and survival outcomes of chronic lymphocytic leukemia in Paraguay.
  • Conducted a retrospective cohort study of patients aged ≥18 with chronic lymphocytic leukemia diagnosed between 2001 and 2024.
  • Data manually extracted from medical records at four centers in Paraguay.
  • Primary endpoint was overall survival; secondary endpoint was progression-free survival.
  • Survival probabilities estimated using Kaplan-Meier and Log-rank tests.
  • 255 patients enrolled with a median age of 65 years; notable male predominance (53.7%).
  • Common clinical presentations included RAI stage 1 (39.5%) and Binet stage A (56.1%).
  • High response rate to treatments observed, with an overall response rate of 88% and a CR rate of 45%.
  • Median overall survival and progression-free survival were not reached during the follow-up period.

Cite This Study

Maria et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4f7https://doi.org/10.1182/blood-2025-7431
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baseline clinical characteristics of patients with chronic lymphocytic leukemia (CLL) from 11 Latin American countries: A real-world registry analysis2025
  2. 2Frontline therapy patterns and outcomes in chronic lymphocytic leukemia: A real-world, multicenter analysis from Latin America.2025
  3. 3Evaluation of clinical and prognostic features and treatment outcomes in patients with chronic lymphocytic leukemia2021
  4. 4Evidence and Equity Gaps in Clinical Care of Chronic Lymphocytic Leukaemia in Portugal: A Real‐World, Multicentre, Cohort Study2026
  5. 5Real-world treatment patterns and outcomes in chronic lymphocytic leukemia: a multicenter retrospective study in Greece2026