What question did this study set out to answer?

This study aims to identify discrepancies in clinical practice versus evidence-based recommendations for chronic lymphocytic leukaemia in Portugal.

April 1, 2026eJHaemOpen Access

Evidence and Equity Gaps in Clinical Care of Chronic Lymphocytic Leukaemia in Portugal: A Real‐World, Multicentre, Cohort Study

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Cohort study identifies care gaps in chronic lymphocytic leukaemia, suggesting improvements for better outcomes.

This study aims to identify discrepancies in clinical practice versus evidence-based recommendations for chronic lymphocytic leukaemia in Portugal.
Retrospective cohort study of CLL patients from five Portuguese hospitals (2018-2020)
Collected demographic, clinical, and genetic data
Analyzed treatment patterns, molecular testing rates, and clinical outcomes
Chemoimmunotherapy was most common (38%); targeted agents used in 32%
TP53 testing in 70% and IGHV testing in 42%, showing variability among centres
Underutilization of targeted therapies, especially in high-risk (77%) and early-relapsing (43%) patients
Five-year overall survival was 73% for first-line and 55% for relapsed/refractory treatments

Esteves et al. (2026) studied this question.

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