What question did this study set out to answer?

This study aims to understand outcomes in Brazilian patients with diffuse large B-cell lymphoma, focusing on the impact of cell origin.

December 8, 2025BloodOpen Access

Non-GCB cell of origin leads to inferior outcomes in brazilian diffuse large B-cell lymphoma patients: Bra-DLBCL multicenter registry, retrospective study of over 500 patients

View Full Paper

Ask AI

Bookmark

Authors

LTLarissa Lane Cardoso TeixeiraHospital Israelita Albert Einstein CFCarolina FeresHospital Israelita Albert Einstein JRJuliana RochaUniversidade Estadual de Campinas (UNICAMP)

Discussion

Member takes

Implication

Multicenter study shows poorer progression-free survival in non-GCB DLBCL patients, suggesting access to better treatments is needed for improved outcomes.

Key Points

This study aims to understand outcomes in Brazilian patients with diffuse large B-cell lymphoma, focusing on the impact of cell origin.
Retrospective observational study utilizing Brazilian multicenter data.
Patient outcomes measured include progression-free survival, overall survival, and non-relapse mortality.
Immunohistochemistry was used for classification into GCB and non-GCB types.
Patients with non-GCB had lower three-year progression-free survival (51%) compared to GCB (67%).
Overall survival was also better in GCB patients (72% vs. 66% in non-GCB).
Higher progression rates were reported in the non-GCB group (37% vs. 25%).
Multivariable analysis revealed non-GCB and extranodal involvement related to greater risk of progression.

Cite This Study

Teixeira et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d54c https://doi.org/10.1182/blood-2025-6323

View Full Paper

Ask AI

Bookmark

Implication

Multicenter study shows poorer progression-free survival in non-GCB DLBCL patients, suggesting access to better treatments is needed for improved outcomes.

Non-GCB cell of origin leads to inferior outcomes in brazilian diffuse large B-cell lymphoma patients: Bra-DLBCL multicenter registry, retrospective study of over 500 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Non-GCB cell of origin leads to inferior outcomes in brazilian diffuse large B-cell lymphoma patients: Bra-DLBCL multicenter registry, retrospective study of over 500 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider