August 1, 2025

Evaluating the Impact of Family History and Polygenic Risk Scores on Cardiometabolic Disease Risk

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Authors

EOEbuka OnyenobiUniversity of Maryland, Baltimore KOKnightess OyiboUniversity of Maryland, Baltimore MZMichael ZhongUniversity of Maryland, Baltimore

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Implication

Cross-sectional analysis assesses the joint effects of family history and polygenic risk scores on cardiometabolic disease risk in adults, suggesting improved risk stratification.

Key Points

Family history significantly increases the risk of all cardiometabolic diseases, particularly obesity (OR: 2.09).
Family history scores are most strongly linked to type 2 diabetes with an odds ratio of 1.40.
Higher polygenic risk scores correlate with elevated disease risk, with the strongest link to type 2 diabetes (OR: 2.25).
Both family history and polygenic risk scores independently contribute to disease risk, enhancing precision prevention strategies.

Cite This Study

Onyenobi et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd43 https://doi.org/10.21203/rs.3.rs-7142452/v1

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Implication

Cross-sectional analysis assesses the joint effects of family history and polygenic risk scores on cardiometabolic disease risk in adults, suggesting improved risk stratification.

Evaluating the Impact of Family History and Polygenic Risk Scores on Cardiometabolic Disease Risk

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluating the Impact of Family History and Polygenic Risk Scores on Cardiometabolic Disease Risk

Discussion

Member takes

Implication

Key Points

Cite This Study

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