Positive family history and high polygenic risk scores independently and jointly increased the risk of cardiometabolic diseases, with their combination conferring over a 2.5-fold risk increase.
Cross-Sectional (n=195,780)
Yes
Does the integration of family history and polygenic risk scores enhance cardiometabolic disease risk stratification?
Integrating family history and polygenic risk scores provides complementary insights that may enhance cardiometabolic risk stratification and guide precision prevention.
Effect estimate: HR 2.07 (95% CI 2.02 - 2.12)
p-value: p=<0.001
Both FH and PRS are associated with CMD risk and provide complementary but distinct insights into disease risk. PRS adds predictive value beyond FH and partially mediates its effect. Integration of both measures may enhance risk stratification and guide precision prevention strategies.
Onyenobi et al. (2026) conducted a cross-sectional in Cardiometabolic diseases (Type 2 diabetes, obesity, hypertension, coronary artery disease) (n=195,780). Positive family history and polygenic risk scores (PRS) vs. Negative family history and intermediate/low PRS was evaluated on Obesity incidence (associated with positive family history) (HR 2.07, 95% CI 2.02 - 2.12, p=<0.001). Positive family history and high polygenic risk scores independently and jointly increased the risk of cardiometabolic diseases, with their combination conferring over a 2.5-fold risk increase.