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August 1, 2025

Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications.

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Authors

ZZZhen ZhangSLShuai LiJSJianjun Sun

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Overview

Meta-analysis demonstrates varying effectiveness of silymarin, Mediterranean diets, and lifestyle modifications for reducing liver disease markers.

Key Points

  • Silymarin combined with Mediterranean diets reduced total cholesterol by 0.39 SMD, suggesting dietary changes can aid liver health.
  • Triglyceride levels decreased significantly with silymarin+medication, indicating effective treatment options for NAFLD.
  • Combination treatments led to substantial reductions in alanine aminotransferase, highlighting the role of lifestyle modifications.
  • Silymarin showed a notable increase in adverse effects, emphasizing the need for careful monitoring during treatment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd96https://doi.org/10.6133/apjcn.202508_34(4).0003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Silymarin Combined with Herbal Medicine on Th17/Treg Cell Imbalance and Inflammatory Response in Patients with Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial2025 · 1 citations
  2. 2Silymarin-choline combination versus ursodeoxycholic acid in non-alcoholic fatty liver disease: A randomized double-blind clinical trial2024 · 1 citations
  3. 3Silymarin treatment and reduction of liver enzyme levels in non-alcoholic fatty liver disease: a case report2023 · 9 citations
  4. 4Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, placebo-controlled trial2024 · 30 citations
  5. 5Impact of silymarin‐supplemented cookies on liver enzyme and inflammatory markers in non‐alcoholic fatty liver disease patients2024 · 6 citations