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August 11, 2025Hepatitis MonthlyOpen Access

Effects of Silymarin Combined with Herbal Medicine on Th17/Treg Cell Imbalance and Inflammatory Response in Patients with Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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Authors

MMMeiqing MaiYWYa WangDWDi Wang

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Overview

Randomized trial demonstrated improved Th17/Treg balance and reduced inflammation in NAFLD patients with silymarin plus TCM, indicating a novel treatment strategy.

Key Points

  • Significant reduction in serum IL-18 by 48.01% in the silymarin + TCM group, enhancing immune balance.
  • Silymarin combined with TCM notably decreased Th17 cell proportions and Th17/Treg ratios, improving patient outcomes.
  • This randomized, double-blind, placebo-controlled trial involved 94 NAFLD patients treated over 12 weeks.
  • Combination therapy may offer a safe, effective management approach for NAFLD, addressing inflammation and immune dysregulation.

Cite This Study

Mai et al. (2025) studied this question.

synapsesocial.com/papers/68af59ddad7bf08b1eade88fhttps://doi.org/10.5812/hepatmon-157416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, placebo-controlled trial2024 · 30 citations
  2. 2Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications.2025
  3. 3Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice2024 · 27 citations
  4. 4Silymarin-choline combination versus ursodeoxycholic acid in non-alcoholic fatty liver disease: A randomized double-blind clinical trial2024 · 1 citations
  5. 5Exploring the therapeutic potential of silymarin-based herbal remedy (prebiotic) and probiotic blend in a mouse model of NAFLD: Insights into gut microbiota modulation and liver health2024 · 5 citations