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August 2, 2025MedicineOpen Access

Tumour budding in gastric and colorectal cancers: A review

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Authors

HZHao ZhangXMXianyu MengDGDongyun Gou

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Overview

This review highlights the significance of tumour budding in gastric and colorectal cancers, indicating its role in tumor metastasis and potential therapeutic targets.

Key Points

  • Tumour budding is a key feature at the edges of gastric and colorectal tumors that influences cancer progression.
  • The presence of tumour budding is associated with more aggressive forms of digestive tract cancers.
  • Methods for grading tumour budding include histological techniques and molecular analyses like lncRNAs and miRNAs.
  • Understanding tumour budding may reveal new therapeutic targets, improving treatment strategies for gastric and colorectal cancers.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8cffbahttps://doi.org/10.1097/md.0000000000042215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Research advances in tumor budding in malignant tumors2026
  2. 2Tumor Budding in Colorectal Carcinoma—From Incidental Observation to Prognostic Marker: Lessons Learned from Colorectal Cancer Assessment2026
  3. 3PERITUMORAL BUDDING AS A PREDICTOR FOR LYMPH NODE METASTASES IN COLORECTAL CARCINOMAS: WHAT IS THE IMPORTANCE?2025 · 1 citations
  4. 4Tumor Budding in Gastric Carcinoma: Beyond Counting Cells at the Invasive Front—A Review of Current Evidence and Biological Perspectives2026 · 3 citations
  5. 5Tumor Budding as a Prognostic Marker in Primary Colon Cancer – A Single Center Experience2024 · 1 citations